Is Combination Therapy Superior to Monotherapy for Painful Diabetic Peripheral Neuropathy?

Authors:
Shilpa Klocke, PharmD, BCPS
Nicole Hahn, PharmD, BCACP

Reviewers:
Elizabeth Hearn, PharmD, BCACP
Jason F. Zupec, PharmD, BCACP

Citation:
Tesfaye S, Sloan G, Petrie J, et al. Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomise Lancet. 2022;400:680-690.

The Problem