Author(s)
Kara Gurries, PharmD, BCACP
Janeen Ibarreta, PharmD
Reviewed By
Joseph Saseen, PharmD, BCPS, BCACP, CLS
Michael Kelly, PharmD, BCACP
Laufs U, Banach M, Mancini GBJ, et al. Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia and Statin Intolerance. J Am Heart Assoc 2019; 8(7): e011662.
The Problem
Therapeutic lifestyle changes and statins are currently the mainstays of treatment for dyslipidemia. Current guidelines recommend statins for primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD) due to their well-established therapeutics benefits. Unfortunately, many patients are unable to tolerate statins due to statin-associated muscle symptoms (SAMS), most commonly manifested as myalgias.1 Patients unable to tolerate a statin can be challenging to treat. Even if the patient is willing to try a lower dose or a different statin, the patient’s low-density lipoprotein cholesterol (LDL-C) may still be above the recommended threshold. This puts patients unable to tolerate statins at increased risk of ASCVD or of a recurrent cardiovascular event.2
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