New evidence from the FRAIL-AF trial suggests that some of our most vulnerable older adults should be maintained on a vitamin K antagonist (like warfarin), rather than switched to a DOAC.
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Direct oral anticoagulants (DOACs) are the standard of care for stroke prevention in most patients with nonvalvular atrial fibrillation (NVAF). Data on the safety and efficacy of DOACS in patients with obesity are limited and, at times, contradictory.
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The patient was referred by her community pharmacists after reporting frequent episodes of hypoglycemia. First visit to this family medicine practice. New onset leg pain and swelling over the past few days.
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In 2023, a targeted update to the American Geriatric Society (AGS) Beers Criteria was published, including a few additions, several removals, and some notable revisions.
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A DOAC would be an attractive alternative to warfarin for many patients with the thrombotic antiphospholipid syndrome. But are they effective?
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There’s no denying that shared decision making (SDM) is an effective communication approach for making patient-centered medical decisions. But studies have yielded mixed results with regard to patient outcomes.
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The VOYAGER PAD trial was the largest trial conducted in patients with PAD following a recent revascularization procedure.
Read MoreThe results of this study reaffirm the safety of apixaban and provide additional evidence to support its preferential use over rivaroxaban.
Read MoreThe PAUSE trial is the first prospective clinical trial to evaluate a standardized perioperative management protocol for patients with AF who use a DOAC.
Read MoreIn Japanese patients with stable CAD and AF, anticoagulation monotherapy with rivaroxaban reduces the rate of major bleeding compared to combination therapy but does not result in an increased risk of cardiovascular events.
Read MoreThe PROSPER study provides important new insights into the benefits and risks of DOACs in older adults (median age = 80 years!) following a cardioembolic stroke due to a-fib.
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The Genetics Informatics Trial (GIFT) examined the potential benefits of using genotype information to personalize the dosing of warfarin therapy in patients undergoing elective hip or knee replacement surgery.
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