Authors:
Benjamin King, PharmD, BCACP
Amber Lilly, PharmD
Jordan Cloonan, PharmD
Reviewers:
Michelle Balli, PharmD, BCACP
Anna K Love, PharmD, BCACP
Citation:
Zimmerman SC, Ferguson EL, Choudhary V, et al. Metformin Cessation and Dementia Incidence. JAMA Netw Open. 2023;6(10):e2339723.
The Problem
Historically, metformin has been the most frequently prescribed medication for type 2 diabetes mellitus (T2DM). Patients with T2DM are at increased risk of dementia; therefore, knowledge about medications and their possible impact on the development of dementia is critical. How does metformin impact the risk of dementia? Should providers be hesitant to prescribe … or discontinue metformin therapy?
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This study did not discuss vitamin B12 deficiency or vitamin B12 use with metformin. It would be interesting to see how these variables affect outcomes.