Archives: Commentaries

Yet another clinical trial attempting to prove that adding a second lipid lowering agent to a statin-based regimen has failed. The Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on...

For diabetes patients uncontrolled on basal insulin therapy, is adding exenatide a good choice? Current treatment algorithms advocate for the addition of prandial insulin in patients who have not reached their glycemic targets...

Should elderly patients with heart failure receive beta-blockers?  SENIORS — a parallel group, randomized, double-blind, multi-center trial comparing nebivolol to placebo — attempted to answer this question.1  Concern...

Clinicians trying to make decisions based on the current best evidence are faced with an overwhelming obstacle, Too Much Information (TMI)! With over 25,000 new randomized controlled trials published each year how can a provider...

Do you tell your patients to take levothyroxine in the morning 30 to 60 minutes before food and at least 4 hours apart from other medications?  It is well known that many medications and foods influence the absorption...

The evidence regarding the benefits of statin therapy in patients with chronic kidney disease has been far from clear. There is no doubt that treatment of low density lipoprotein cholesterol (LDL-C) with statins reduces coronary...

The wait for alternatives to warfarin for stroke prevention in atrial fibrillation has been a long one. Patients and clinicians have long noted the limitations of warfarin, with dietary restrictions, drug-interactions and...

For patients with atrial fibrillation, what’s the best scoring system to estimate stroke risk? Clinicians have long relied on the CHADS2 [congestive heart failure, hypertension, age ≥ 75 years, diabetes, and previous stroke or...