Author(s)
Mary K. Culp, PharmD
Diana Isaacs, PharmD, BCPS, BCACP, BC-ADM, CDCES
Reviewers:
Jennifer N. Clements, PharmD, BCPS, BCACP, BC-ADM, CDCES
Abigail Klutts, PharmD
Lauren Longaker, PharmD
Citation: Breton MD, Kanapka LG, Beck RW, et al. A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes. N Engl J Med. 2020;383(9):836-845. doi:10.1056/NEJMoa2004736
The Problem
More than 18,000 children in the United States were diagnosed with type 1 diabetes mellitus (T1DM) between 2014 and 2015.1,2 However, this statistic only represents a fraction of the lives impacted by the stress of managing the disease because T1DM affects the entire family. Moreover, the rate of new diagnoses of T1DM is increasing in both children and adults. 1,2 Insulin pumps and continuous glucose monitors (CGM) have changed the standard of care for managing T1DM.3 Closed-loop insulin pumps may offer an opportunity to improve glycemic management while alleviating some of the associated stress. However, there are limited data evaluating the safety and efficacy of this technology in children less than 14 years old.
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