Could a commonly prescribed antibiotic, when combined with a renin-angiotensin system inhibitor, lead to sudden death? Angiotensin converting enzyme inhibitors (ACE-I), angiotensin receptor blockers (ARB), and spironolactone are frequently used in older adults for a variety of indications. All can potentially cause hyperkalemia.1-2 Co-trimoxazole (trimethoprim-sulfamethoxazole) is commonly prescribed for a wide range of infections. One study found that when co-trimoxazole... Read More
We all have an innate desire for clarity in our decisions. Often, however, we are faced with controversy and uncertainty. Grey areas where there is a gap between clinical practice, logical reasoning, and evidence. One of these grey areas is the “right” approach to the peri-procedural management of chronic anticoagulation. There are so many clinical decisions involved (See Table 1) and little clarity about any of them!
Table 1: Clinical questions regarding the peri-... Read More
Direct-acting antiviral agents for the treatment of hepatitis C infection are revolutionizing how we treat patients. What is the hype all about? Are these medications worth it? Our panelists critically examine the results of the ION2 Study, providing insights on these questions and more.